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炎症性卡斯帕酶-4对细胞因子分裂的结构洞察

Pascal Devant1, Ying Dong2,3, Julian Mintseris4

  • 1Division of Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

Nature
|November 22, 2023
PubMed
概括

人类卡斯帕斯4可以通过绕过炎症体和卡斯帕斯1来切割互白素-18 (IL-18). 化EM揭示了与气体皮质D不同的酶-4细胞因子处理和基质捕获的结构机制.这影响了先天免疫研究.

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