调查英国一般实践中痛风爆发和管理的队列研究
Samuel Finnikin1, Christian D Mallen2, Edward Roddy2,3
1Institute of Applied Health Research, University of Birmingham, Birmingham, B15 2TT, UK. s.j.finnikin@bham.ac.uk.
BMC primary care
|November 22, 2023
概括
大约六分之一的痛风患者在一年内会出现复发性发作. 尿酸降低疗法 (ULT) 的启动往往会延迟,尽管影响发作和治疗的因素相似.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 初级医疗保健医学 一级医疗保健医学
背景情况:
- 痛风是一种普遍的炎症性关节炎,通常在初级保健中进行治疗.
- 痛风的过程和严重程度是高度可变的,并未被充分理解.
- 这项研究涉及英国痛风发作和尿酸降低疗法 (ULT) 启动的频率和因素.
研究的目的:
- 为了调查英国痛风爆发的频率.
- 为了确定与痛风爆发和ULT开始相关的因素.
- 描述患者从痛风诊断到ULT启动的过程.
主要方法:
- 利用临床实践研究数据库来识别发生痛风的患者.
- 分析了处方和编码数据以识别痛风爆发和ULT启动.
- 采用Cox比例危险模型和后勤回归来分析相关因素.
主要成果:
- 分析了超过51000名患者;35.9%的人至少经历过一次复发性爆发.
- 诸如男性性别,黑人种族,更高的BMI,心力衰竭,CKD,CVD和利尿剂使用等因素与爆发有关.
- 在27.7%的患者中启动了ULT,诊断后观察到显著的延迟.
结论:
- 每六个新确诊的痛风患者中就有一人在12个月内经历了随后的爆发.
- 影响发作复发和ULT启动的因素相似.
- 在痛风诊断后,ULT启动往往比预期晚发生.
相关概念视频
Peptic Ulcer Disease IV: Management
95
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
95
Acute Pancreatitis II: Clinical Manifestations and Management
130
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
130
Chronic Pancreatitis II: Collaborative Care
94
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
94
Inflammatory Bowel Disease IV: Pharmacological Management
132
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
132
Genome-wide Association Studies-GWAS
13.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.5K
Gastritis III: Clinical Manifestations and Management
281
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
281


