成年人注意力缺陷/多动障碍症状和随后的心脏代谢障碍:通过纵向双胞胎研究调查潜在机制
Maja Dobrosavljevic1, Ralf Kuja-Halkola2, Lin Li2
1School of Medical Sciences, Faculty of Medicine and Health, Örebro University, SE-701 82, Örebro, Sweden. maja.dobrosavljevic@oru.se.
BMC medicine
|November 23, 2023
概括
成年时注意力缺陷/多动症 (ADHD) 症状与心血管和代谢疾病风险增加有关. 这些关联可以通过教育程度,生活方式和遗传因素来解释.
科学领域:
- 精神病学是一个精神病学.
- 心脏病学 心脏病学
- 代谢健康 代谢健康
背景情况:
- 新兴研究将注意力缺陷/多动障碍 (ADHD) 与成人心血管疾病 (CVD) 和代谢障碍风险的增加联系起来.
- 之前的研究是有限的,主要集中在被诊断的ADHD病例上.
研究的目的:
- 调查年轻人和中年人的ADHD症状与随后的心脏代谢障碍之间的潜在关联.
- 探索潜在的机制,包括教育程度,生活方式,精神病并发症和遗传因素.
主要方法:
- 利用了瑞典双胞胎登记处的10,394名双胞胎 (1958-1985年出生) 的数据.
- 通过经过验证的尺度 (2005-2006) 评估了ADHD症状,并追踪了心脏代谢障碍直到2018年.
- 采用考克斯回归和共同双胞胎控制设计来分析关联和家庭混.
主要成果:
- 患ADHD症状增加1个单位与心血管疾病发生率提高2%和代谢障碍发生率提高3%相关.
- 在调整了教育,生活方式和精神病并发症后,关联变得无意义.
- 遗传因素部分混了这些关联,特别是在心血管疾病方面.
结论:
- ADHD症状得分与心脏代谢障碍风险增加有关,可能由教育,生活方式和精神病因素介导.
- 共同的遗传因素似乎起到了作用,特别是在心血管疾病风险方面.
- 建议进行进一步的研究,以检查特定疾病和长期结果.
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