在具有相似客观认知轨迹的群体中了解与主观认知投诉轨迹相关的因素
Federica Cacciamani1,2,3,4, Ariane Bercu5, Vincent Bouteloup5,6,7
1UMR 1219, Bordeaux Population Health Center, University of Bordeaux, Inserm, Bordeaux, F-33000, France. federica.cacciamani@u-bordeaux.fr.
Alzheimer's research & therapy
|November 23, 2023
概括
患有阿尔茨海默氏病 (AD) 风险的个人的主观认知投诉各不相同,受AD生物标志物和非AD因素 (如抑郁症和并发症) 的影响. 了解这些因素对于解释认知变化至关重要.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 精神病学是一个精神病学.
背景情况:
- 认知投诉可以信号早期阿尔茨海默病 (AD),但也发生在其他条件.
- 这项研究调查了影响认知投诉轨迹的因素,这些因素影响了具有类似客观认知变化的个体.
研究的目的:
- 在具有相似客观认知轨迹的个体中,在五年内检查认知投诉轨迹的相关性.
- 要区分影响主观认知问题的与AD相关的和非AD相关的因素.
主要方法:
- 分析了从主观认知衰退或轻度认知障碍的MEMENTO队列中取出的子样本 (n=1748).
- 根据迷你心理状态检查 (MMSE) 轨迹分层参与者 (高/增加,微妙下降,急剧下降).
- 使用潜伏类纵向分析来分析投诉轨迹,并对与AD生物标志物,心理健康,社会因素和并发症的关联进行后勤回归.
主要成果:
- 在患有高/增加MMSE的参与者中,较高的并发症-多药性得分与中度/增加的认知投诉相关.
- 在微妙的MMSE下降的参与者中,较高的抑郁症得分与中度/增加的认知投诉有关.
- 同病多药性和抑郁症显示与投诉模式的关联,尽管有些人没有经历多次比较纠正.
结论:
- 主观认知投诉的异质性存在,尽管有相似的客观认知轨迹.
- 与AD相关的和非AD相关的因素,特别是抑郁症和并发症,都显著影响人们对认知变化的看法.
- 这些发现凸显了痴呆风险较高的人群主观认知问题的复杂性.
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