早期多重系统缩中睡眠障碍的纵向演变:为期2年的前性队列研究
Lingyu Zhang1,2, Yanbing Hou1, Chunyu Li1
1Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
BMC medicine
|November 23, 2023
概括
睡眠障碍,如过度的白天嗜睡和与帕金森病相关的睡眠问题,在早期多重系统缩 (MSA) 中,在两年内恶化. 对MSA患者来说,早期评估和管理这些睡眠问题至关重要.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 神经退行性疾病 神经退行性疾病
背景情况:
- 早期多重系统缩 (MSA) 睡眠障碍的进展情况尚不清楚.
- 在REM睡眠行为障碍 (RBD),过度白天嗜睡 (EDS) 和帕金森病相关睡眠问题 (PD-SP) 中的纵向变化需要进一步调查.
研究的目的:
- 调查MSA早期患者睡眠障碍频率,严重程度和共存的2年纵向变化.
- 为了确定RBD,EDS和PD-SP随时间推移的进展模式.
主要方法:
- 纳入了早期MSA患者 (疾病持续时间<3年).
- 2年后的后续评估包括RBD查问卷,爱普沃思睡眠度量表和PD睡眠度量表-2.
- 招募了220名患者,其中90人完成了为期2年的随访.
主要成果:
- 在MSA患者中,所有评估的睡眠障碍在2年内都显示得分增加 (p < 0.05).
- PD-SP (14.5%至26.7%) 和EDS (17.7%至37.8%) 的发生频率显著增加 (p < 0.05).
- 随着时间的推移,RBD频率略有增加 (51.8%至65.6%,p = 0.152),多个睡眠障碍的共存也随着时间的推移而增加.
结论:
- 睡眠障碍,除了RBD,在MSA早期的频率逐渐增加.
- 随着时间的推移,两个或两个以上睡眠障碍的同时发生变得越来越常见.
- 建议对早期MSA患者进行睡眠障碍的早期查和管理.
相关概念视频
01:15REM Sleep Behavior Disorder
206
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
206
01:24Sleep-Wake Cycles
1.4K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.4K
01:07Narcolepsy
109
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
109
01:22Stages of Sleep
199
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
199
01:11Understanding Sleep
234
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
234