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Updated: Jul 10, 2025

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大规模的并行测序揭示了卵泡树突细胞肉瘤的同源重组缺陷

Luisa Lorenzi1, Torsten Haferlach2, Luigi Mori3

  • 1Pathology Unit, ASST Spedali Civili di Brescia, Department of Molecular and Translational Medicine, University of Brescia, Brescia. luisa.lorenzi@unibs.it.

Haematologica
|November 23, 2023
PubMed
概括

状树突细胞肉瘤 (FDCS) 的分子景观揭示了瘤抑制基因的频繁突变. 这种罕见的癌症可能受益于多ADP核糖聚合酶抑制剂,而不是免疫检查点抑制剂.

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Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
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