疾病中的ILC3s和适应性免疫之间的交叉关系
Wenyan Wang1,2,3, Na Li1,2,3, Xiaohuan Guo1,2,3
1Institute for Immunology, Tsinghua University, Beijing, China.
The FEBS journal
|November 23, 2023
概括
第三组先天性淋巴细胞 (ILC3s) 对于宿主防御和组织平衡至关重要. 它们与适应性免疫细胞的相互作用对于理解疾病和开发新疗法至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 3组先天性淋巴细胞 (ILC3s),表达RORγt,是在粘膜和淋巴组织中发现的先天性免疫细胞.
- ILC3s是T助手17 (Th17) 细胞的先天对应物,在宿主防御感染中发挥关键作用.
- 最近的研究强调了ILC3s和自适应性免疫细胞,特别是T细胞之间的交叉声的关键作用,以维持组织平衡.
研究的目的:
- 审查了解ILC3s和自适应性免疫反应之间的交叉交流的最新进展.
- 探索这种相互作用对各种组织和疾病的影响.
- 根据ILC3适应性免疫细胞参与,识别潜在的治疗点.
主要方法:
- 关于ILC3s和适应性免疫的最新研究的文献综述.
- 对ILC3与不同类型的免疫细胞相互作用的分析.
- 检查ILC3在各种组织环境和疾病环境中的作用.
主要成果:
- ILC3s通过效应分子积极与各种细胞交互,为宿主防御做出贡献.
- ILC3s与适应性免疫细胞,特别是T细胞之间的交叉交互对于维持组织平衡至关重要.
- 这种相互作用涉及到多种组织和疾病病理.
结论:
- 了解ILC3适应性免疫细胞相互作用对于推进免疫学知识至关重要.
- 对这种交叉语音的进一步研究可以提高对疾病机制的理解.
- 确定针对ILC3与自适应免疫的接触的新型治疗策略,为未来的治疗提供了希望.
相关概念视频
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Cell-mediated Immune Responses
68.4K
Overview
68.4K
Cells of the Adaptive Immune Response
994
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
994
T Cell Activation and Clonal Selection
747
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
747
Special Features of Adaptive Immunity
834
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
834
B Cell Activation and Differentiation
1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K


