移植中的天生的免疫细胞疗法
1Department of General Surgery, Boston Children's Hospital, Boston, MA, United States.
Frontiers in transplantation
|November 23, 2023
概括
利用天生的免疫系统为防止器官移植排斥提供了一个有希望的新途径. 先天性免疫细胞,如髓质衍生抑制细胞和巨细胞,显示出作为改善长期移植成功的新疗法的潜力.
科学领域:
- 移植免疫学 移植免疫学
- 这是天生的免疫力.
- 细胞治疗学 细胞治疗学
背景情况:
- 目前用于器官移植的免疫抑制策略具有重大风险.
- 通过自适应性免疫操纵促进全移植耐受性已经产生令人失望的长期存活率.
- 人们越来越认识到天生的免疫系统在移植排斥和潜在的治疗应用中的作用.
研究的目的:
- 审查先天免疫细胞在非免疫反应中的作用.
- 探索先天免疫细胞在移植中的治疗潜力.
- 讨论先天细胞疗法临床转化方面的挑战和未来方向.
主要方法:
- 关于移植中的先天性免疫细胞的当代研究的综述.
- 分析特定的先天免疫细胞类型的特征和功能.
- 检查治疗应用和临床翻译挑战.
主要成果:
- 天生的免疫细胞,包括髓质衍生抑制细胞,树突细胞,调节性巨细胞,自然杀手细胞和天生的淋巴细胞,参与移植排斥.
- 这些细胞可以进行功能性重编程,称为训练免疫.
- 几种先天性免疫细胞类型正在作为潜在的基于细胞的治疗方法进行研究.
结论:
- 天生的免疫细胞是预防和治疗器官移植排斥的有希望的治疗标.
- 准先天性免疫细胞中训练有素的免疫力可能会导致更好的全移植存活率.
- 需要进一步的研究和临床调查,以克服翻译这些疗法的挑战.
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