在南非西开普省与SARS-CoV-2Delta变种相关的较高死亡率,使用RdRp目标延迟作为代理:一个横截面研究
Hannah Hussey1,2, Mary-Ann Davies1,3, Alexa Heekes1,2
1Health Intelligence, Western Cape Government: Health, Cape Town, South Africa.
Gates open research
|November 23, 2023
概括
与Beta变种相比,SARS-CoV-2的Delta变种在南非显示死亡率增加. 疫苗接种和先前感染提供了防止严重后果的保护.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 虽然SARS-CoV-2的三角形变体 (B.1.617.2) 与严重的疾病有关,但非洲地区的数据有限.
- 与非洲的Beta变种相比,了解Delta的严重程度至关重要.
研究的目的:
- 在南非西开普省评估SARS-CoV-2Delta变种的疾病严重程度.
- 为了比较Delta和Beta变体之间的死亡风险,使用一种新的代理标记.
主要方法:
- 一个代理标记物,RNA依赖RNA聚合酶 (RdRp) 在PCR试验中的点延迟,确定了疑似的Delta变种感染.
- 分析了来自南非西开普省 (2021年4月至7月) 的例行实验室,住院和死亡数据.
- 调整后的几率比率计算了与Delta代理相关的死亡率,控制了先前的感染和接种疫苗.
主要成果:
- 疑似感染Delta变种 (RdRp目标延迟) 与Beta变种 (aOR 1.45) 相比,死亡风险增加了45%.
- 在Beta波期间的先前感染 (aOR 0.32) 和完整的疫苗接种 (aOR 0.15) 对死亡有保护作用.
- 这项研究包括11,355例病例和700例死亡.
结论:
- 德尔塔变种的代理标志物表明,在研究的南非人口中,死亡风险增加.
- 这一发现凸显了在全球不同环境下,三角洲变种对公众健康的重大影响.
- 接种疫苗和以前的感染仍然是针对严重COVID-19结果的关键干预措施.
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