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皮质转化,白质微观结构和表型特征在药物先验强迫症疾病中的关联

Jianyu Li¹, Jian Cheng², Lei Yang³

¹School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.

Psychological medicine

|November 23, 2023

概括

强迫症 (OCD) 与大脑连接的改变有关. 这项研究发现强迫症患者皮层折叠增加和白质结构异常,与焦虑水平相关.

科学领域:

神经科学是一个神经科学.
神经成像是一种神经成像.
精神病学是一个精神病学.

背景情况:

强迫症 (OCD) 与大脑失联性有关.
皮层转化,大脑折叠的度量,可能反映出早期发育连接性.
研究转化变化的研究可以揭示强迫症的发育起源.

研究的目的:

为了检查皮质转化和白质微观结构的变化在药物先验的强迫症患者.
探索这些神经成像发现与焦虑症状之间的关系.

主要方法:

使用T1加权的MRI计算62名强迫症患者和59名健康对照者的局部化指数 (LGI).
采用扩散权重的MRI来评估大脑中白质总扭曲.
与焦虑分数相关的LGI和扭曲措施.

主要成果:

与HC患者相比,强迫症患者在中间额头和右前肌中显著增加了LGI.
患有强迫症的患者显示,体的总扭曲明显减少.
强迫症中LGI增加和白质几何变化与焦虑严重程度相关.

结论:

在高的LGI,异常的白质几何学和强迫症中增加的焦虑之间有明显的关联.
表明导致皮层折叠变化的发育性失联性是强迫症症状的神经基质.

关键词:

发育性失联性发展性失联性导演现场分析现场分析化化化化化强迫症是一种强迫性障碍.

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