在死后尿样中测量心型脂肪酸结合蛋白的有用性
Waka Hisamura1, Shojiro Takasu, Kimiharu Iwadate
1From the Department of Forensic Medicine, Jikei University School of Medicine: Tokyo Jikeikai Ika Daigaku, Tokyo, Japan.
The American journal of forensic medicine and pathology
|November 23, 2023
概括
与对照组相比,死后尿液中心型脂肪酸结合蛋白 (HFABP) 的水平在急性心肌梗塞,败血症和热中风病例中较高. 尿液HFABP测量可能有助于确定死亡原因.
科学领域:
- 法医病理学 法医病理学
- 生物标记分析 生物标记分析
- 毒理学 毒理学 毒理学
背景情况:
- 心型脂肪酸结合蛋白 (HFABP) 是通过脏分泌的,这表明尿液水平可能反映死前血液度.
- 调查HFABP作为特定死因的死后生物标志物是有必要的.
研究的目的:
- 为了评估死后尿液HFABP度的诊断有效性.
- 为了将尿液中的HFABP水平与脏组织对HFABP的免疫染相关联.
主要方法:
- 在94例法医解剖病例中测量了死后尿液HFABP.
- 在急性心肌梗塞 (AMI),败血症,热中风和窒息 (对照组) 之间的尿液HFABP水平的比较.
- 针对HFABP的脏组织的免疫结合,以评估与尿路测量的相关性.
主要成果:
- 与窒息控制组相比,在AMI,败血症和热中风病例中,尿液中的HFABP水平显著升高.
- 两组之间没有观察到对HFABP的脏组织定量免疫分泌的显著差异.
- 对HFABP的免疫染在阐明死亡原因方面具有很小的效用,可能是由于死后的变化和寡尿症.
结论:
- 死亡后的尿液HFABP测量显示在确定死亡原因方面具有潜在的实用性.
- 在这种情况下,脏HFABP免疫染色不是确定死亡原因的可靠方法.
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