美国皮肤状细胞癌患者的大型皮肤手术和重建的模式
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Establishment of a Clinic-based Biorepository
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Chieh-I Chen1, Jessica J Jalbert1, Ning Wu1
1Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.
Future oncology (London, England)
|November 23, 2023
概括
大约11%的皮肤状细胞癌 (CSCC) 患者需要在7年内进行重大手术. 对于那些接受全身疗法或免疫受损的人来说,这种风险显著增加.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 手术瘤学手术瘤学
背景情况:
- 大型皮肤手术和重建是皮肤状细胞癌 (CSCC) 的常见情况.
- 关于CSCC患者这些手术的频率和风险因素的数据有限,特别是那些接受全身治疗或免疫状况不同的人.
研究的目的:
- 在新诊断的CSCC患者中量化重大皮肤手术/重建的发生率.
- 评估在接受全身治疗的CSCC患者中这些程序的风险.
- 根据患者的免疫状况对手术风险进行分层.
主要方法:
- 在2013-2020年期间使用了Optum Clinformatics Data Mart数据库.
- 确定了450,803名发生CSCC的患者,其中包括4,111名开始系统治疗的患者.
- 采用卡普兰-梅尔估计器来确定重大皮肤手术/重建的7年风险.
主要成果:
- 在所有CSCC患者中,重大皮肤手术/重建的7年风险为10.9%,在全身治疗患者中为21.8%.
- 开始全身治疗的患者出现了接受重大手术/重建的更高风险.
- 与免疫能力较强的个体相比,免疫功能低下的患者的整体风险更高.
结论:
- 大约11%的CSCC患者在诊断后7年内至少进行一次重大皮肤手术/重建.
- 在开始全身治疗的CSCC患者中,重大手术/重建的风险增加.
- 免疫受损状态与CSCC患者发生重大皮肤手术/重建的风险较高有关.
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