日本头癌患者中长期存活率的特定亚站点趋势:基于人口的研究
Hiroshi Tsuge1,2, Daisuke Kawakita2, Yukari Taniyama1
1Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
Cancer science
|November 23, 2023
概括
头癌 (HNC) 的生存率在日本整体上有所改善,但在癌症子部位的进展不均. 一些HNC类型显示显著的生存收益,而其他类型,如喉癌,已经看到微小的改善.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 头癌 (HNC) 的预后受到诊断和治疗进步的影响.
- 在HNC中特定的子站点生存趋势仍然不完全理解.
- 基于人口的数据对于评估长期生存率变化至关重要.
研究的目的:
- 评估脑癌 (HNC) 患者中长期存活率的部位特异性趋势.
- 分析日本1993年至2011年HNC存活率的变化.
- 为了确定不同HNC子站点的生存改善的差异.
主要方法:
- 利用了来自日本13个基于人口的癌症登记册 (1993-2011) 的数据.
- 估计的净存活率 (NS) 对于HNC,按次站点划分.
- 采用多变量过度危险模型来评估随时间变化的死亡率,根据年龄,性别和阶段进行调整.
主要成果:
- 在日本,HNC患者的整体5年净生存率 (NS) 改善.
- 在鼻,口和鼻下的癌症中观察到显著的5年和10年NS改善.
- 喉癌仅在5年内略有NS改善,在10年内没有显著的NS变化.
结论:
- 在HNC诊断和治疗方面的进步导致了更好的生存结果.
- 在所有HNC子站点中,生存率的改善并非均分布.
- 这项研究强调了需要有针对性的策略,以解决特定HNC子站点的生存差异.
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