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关节和外腔皮质类固醇注射后的SARS-CoV-2风险:一项回顾性研究
Robin Raju1, Eric K Holder1, Mark Dundas1
1Department of Orthopedics and Rehabilitation, Yale New Haven Hospital/Yale University, New Haven, Connecticut, USA.
皮质类固醇注射并没有增加SARS-CoV-2的整体阳性. 然而,它们与严重并发症的接种疫苗的患者3个月后的阳性反应更高有关.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 类风湿病学 类风湿病学
背景情况:
- 皮质类固醇 (CS) 注射的免疫抑制作用在COVID-19大流行期间引起了人们的担忧.
- 了解CS注射和SARS-CoV-2阳性之间的联系至关重要.
研究的目的:
- 调查关节/外皮 CS 注射与SARS-CoV-2聚合酶链反应 (PCR) 阳性之间的关联.
- 评估CS注射是否影响COVID-19感染率.
主要方法:
- 对18岁以上接受CS注射的患者的回顾性图表审查与对照组相比.
- 在CS注射和对照组之间的SARS-CoV-2PCR阳性率的比较.
- 多变量回归分析调整并发病症和年龄.
主要成果:
- 在CS注射 (12.27%) 和对照 (11.90%) 组之间,整体SARS-CoV-2 PCR阳性没有显著差异.
- 在CS注射组中观察到一个统计学上显著的3个月后SARS-CoV-2 PCR阳性率 (3.30%对2.10%).
- 调整后的分析显示,在CS组中,严重并发症患者的3个月阳性反应更高,特别是在接种疫苗的子组中.
结论:
- 该研究并没有最终确定CS注射与SARS-CoV-2 PCR总体阳性之间的联系.
- 经过调整后的分析表明,在患有严重并发症的患者中,在CS注射后,SARS-CoV-2阳性3个月的潜在增加.
- 需要进一步的研究来澄清细微的关系,特别是在特定的患者子组.
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