间歇性缺氧训练有效地防止由急性缺氧暴露引起的认知衰退
Guangbo Zhang1,2, Guochun Yang3, Yanzhao Zhou1
1Department of Cognition Sciences and Stress Medicine, Beijing Institute of Basic Medical Sciences, No. 27 Taiping Road, Haidian District, Beijing, China.
间歇性缺氧训练 (IHT) 有效地缓解急性山病 (AMS),并在缺氧暴露期间改善认知功能和大脑血流. 这种训练方法可以帮助预防大脑胀和高海拔地区的认知障碍.
科学领域:
- 高度生理学 高度生理学
- 神经科学是一个神经科学.
- 运动科学 运动科学 运动科学
背景情况:
- 间歇性缺氧训练 (IHT) 有助于适应和降低急性山病 (AMS) 的风险.
- 在低氧后,IHT对认知和脑血管功能的影响尚不清楚.
研究的目的:
- 评估简化IHT范式在缓解AMS方面的有效性.
- 研究IHT在急性缺氧期间对认知和神经功能的影响.
- 评估IHT在缺氧后对大脑胀和脑血流 (CBF) 的影响.
主要方法:
- 一个简化的间歇性缺氧训练 (IHT) 协议被管理.
- 参与者在4300米处接受了急性缺氧暴露.
- 评估了认知功能,神经变化,脑部胀 (MRI) 和脑血流 (CBF).
主要成果:
- 在4300m时,IHT范式有效地缓解了AMS症状.
- IHT显著改善了认知功能,包括工作记忆,冲突控制和认知控制,同时减少了精神疲劳.
- 磁共振成像显示,在IHT组中,缺氧诱导的大脑胀的逆转.
- 在IHT组中,在多个大脑区域观察到脑血流 (CBF) 的增加.
结论:
- 简化间歇性缺氧训练 (IHT) 有助于适应和缓解AMS.
- 在低氧条件下,IHT可以提高认知能力和神经功能.
- 通过增加大脑血液流动,IHT可以改善大脑胀和认知功能障碍.
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