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微生物群的变化及其与分子调节的相关性在PCOS患者中潜在的抑郁症

Liying Yu¹, Xiaoyu Chen², Xuefeng Bai²

¹Central Laboratory, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China. yly@fjmu.edu.cn.

Molecular neurobiology

|November 23, 2023

概括

多囊卵巢综合征 (PCOS) 中的抑郁症与肠道微生物组的变化有关. 在患有抑郁症的PCOS患者中,特定的细菌和宿主基因表达转移提供了潜在的诊断和治疗点.

科学领域:

生殖内分泌学和新陈代谢
微生物组研究微生物组研究
神经精神病学是一种神经精神病学.

背景情况:

多囊卵巢综合征 (PCOS) 经常与抑郁症相关,影响女性的心理健康.
人们越来越认识到肠道微生物组在PCOS和抑郁症中的作用,但其对PCOS患者抑郁症的具体影响仍然不清楚.

研究的目的:

调查肠道微生物群组成,宿主基因表达和PCOS妇女抑郁症之间的关系.
确定PCOS患者抑郁症的潜在微生物和分子生物标志物.

主要方法:

采用元基因组测序来分析便微生物群组成.
利用转录组测序 (RNA-seq) 来对外围血液单核细胞中的基因表达进行分析.
将患有PCOS (PCOS-DP) 的抑郁女性与健康的PCOS,严重抑郁症 (MDD) 和健康的对照 (HC) 组进行了比较.

主要成果:

与HC,MDD和PCOS组相比,在PCOS-DP中观察到明显的肠道微生物群模式,如Ruminococcus torques和Bacteroides eggerthii等特定微生物的丰度发生了变化.
RNA-seq发现了基因表达的显著差异,其中与信号转导,内分泌/代谢疾病和脂质代谢相关的途径受到影响.
与微生物群相关的基因在神经退行性疾病和免疫系统途径中被丰富,这表明系统性影响.

结论:

多omics数据显示,在患有抑郁症的PCOS患者中,肠道微生物组和宿主基因调节的显著转变.
特定的肠道微生物 (例如,Bacteroides eggerthii) 和宿主基因 (例如,CREB3L3,CCDC173) 可能作为潜在的病因因素,诊断生物标志物和PCOS相关抑郁症的治疗点.

关键词:

抑郁症是一种抑郁症.肠道微生物肠道微生物甲基基因组是指甲基因组中的一部分.在PCOS中,PCOS是PCOS.转录组转录组就是一个转录组.

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