p120 RasGAP和ZO-2对于Hippo信号传递和由p190A RhoGAP介导的瘤抑制功能至关重要

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Hanyue Ouyang1, Shuang Wu2, Wangji Li3

  • 1GI Cell Biology Laboratory, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P.R. China.

Cell reports
|November 23, 2023
PubMed
概括

通过激活Hippo通路,ARHGAP35 (p190A) 起到瘤抑制作用. 它与RasGAP和ZO-2的相互作用对于瘤抑制和细胞增殖控制至关重要,影响患者的生存.

关键词:
在阿尔赫加普3535CP: 癌症 癌症 癌症科普:分子生物学 分子生物学河马的路径 河马的路径在RASA1中,RASA1是指RASA1,RASA1是指RASA1.拉斯 (Ras) 信号传输是什么意思在Rho信号传输中.在TJP1/2中.在 ZO-1/2 中.p120 RasGAPAP的使用情况p190 在RhoGAPAP中使用.这是一种瘤抑制剂.

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