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Updated: Aug 16, 2026

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在小鼠外围神经损伤后,巨细胞的采用细胞转移

Atul Rawat1, Mithilesh Kumar Jha1, Brett Michael Morrison1

  • 1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

STAR protocols
|November 23, 2023
PubMed
概括

这项研究详细介绍了一种转移骨髓衍生巨细胞 (BMDMs) 的方法,以帮助外周神经在受伤后再生. 这些细胞可以改善功能恢复,为神经损伤提供潜在的新疗法.

关键词:
细胞培养 细胞培养免疫学 免疫学 免疫学模型生物模型生物

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...