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相关概念视频

Combinatorial Gene Control02:33

Combinatorial Gene Control

8.4K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
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Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

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Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Complementary DNA01:44

Complementary DNA

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Overview
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Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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相关实验视频

Updated: Jul 10, 2025

Divergence of Root Microbiota in Different Habitats based on Weighted Correlation Networks
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Divergence of Root Microbiota in Different Habitats based on Weighted Correlation Networks

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COMMO:一个用于识别和分析多种方法共识基因模块的Web服务器.

Xiaojing Wu1,2, Mingfei Han2, Xinyu Song3

  • 1Basic Medical School, Anhui Medical University, Hefei 230022, China.

Bioinformatics (Oxford, England)
|November 23, 2023
PubMed
概括

COMMO是一个新的网络服务器,集成了多种基因模块检测方法,以找到共识基因模块. 该工具通过提供对基因表达数据的强大分析,有助于精准医学研究.

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Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
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Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project
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Last Updated: Jul 10, 2025

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Divergence of Root Microbiota in Different Habitats based on Weighted Correlation Networks

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Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
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科学领域:

  • 计算生物学 计算生物学
  • 生物信息学是一种生物信息学.
  • 基因组学就是基因组学.

背景情况:

  • 从全基因组表达数据中识别功能相关的基因模块对于理解生物过程至关重要.
  • 整合来自多种计算方法的结果可以提高基因模块识别的准确性和稳定性.

研究的目的:

  • 推出COMMO,这是第一个用于识别和分析来自不同检测方法的共识基因功能相关模块的Web服务器.
  • 为基于模块的精准医学研究提供一个用户友好的平台.

主要方法:

  • COMMO实现了八种最先进的模块检测算法和两个共识集群方法.
  • 它为33种癌症类型提供集成的mRNA和蛋白质表达数据,并允许用户上传自定义数据集.
  • 功能丰富和生存分析是对已识别的基因模块进行的.

主要成果:

  • 在COMMO网络服务器上,可以识别和分析共识基因模块.
  • 它提供交互式可视化和可导出结果,用于全面的数据探索.
  • 该平台支持各种癌症类型的基于模块的研究.

结论:

  • 为了识别共识基因模块,COMMO提供了一个全面且易于使用的解决方案.
  • 它的综合方法和分析能力促进了基于模块的精密医学研究的进步.