COVID-19治疗方法:英格兰的管理和对抗菌素耐药性的考虑
Sabine Bou-Antoun1, Sakib Rokadiya2, Diane Ashiru-Oredope1
1Healthcare-Associated Infection (HCAI), Fungal, Antimicrobial Resistance (AMR), Antimicrobial Use (AMU) & Sepsis Division, United Kingdom Health Security Agency (UKHSA), London, UK.
英国实施了抗菌药物管理和监测,以保持COVID-19直接作用抗病毒 (DAA) 的有效性,并监测抗病毒耐药性. 这种方法支持DAA的部署,安全性和针对SARS-CoV-2的有效性.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- COVID-19大流行刺激了疫苗,诊断和直接作用抗病毒药物 (DAA) 的快速开发和分发.
- 在预防SARS-CoV-2感染患者的严重疾病方面,DAA至关重要.
- 对DAA的抗病毒耐药性 (AVR) 存在担忧,DAA是一种特定形式的抗菌素耐药性 (AMR).
研究的目的:
- 描述英格兰的公共卫生活动,以支持DAA的管理.
- 评估DAA对COVID-19的部署,安全性,有效性和耐药性潜力.
- 为了检测赋予DAA耐药性的突变.
主要方法:
- 流行病学监测以追踪疾病传播和治疗模式.
- 病毒学监测监测病毒演变并识别耐药性标记物.
- 基因组监测分析与DAA疗效相关的SARS-CoV-2遗传变化.
主要成果:
- 持续的监督和管理计划对于管理DAA至关重要.
- 这些综合公共卫生活动支持治疗药物的安全和有效使用.
- 通过强大的监测系统,可以更容易地早期检测出抗性潜力.
结论:
- 抗菌药物管理和全面监测对于保持DAA对SARS-CoV-2的有效性至关重要.
- 这些策略对于管理新出现的抗病毒耐药性至关重要.
- 持续监测确保了DAA在COVID-19治疗中的长期效用.
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