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特兰胺酸 (I类药物) 降低和封顶黄金纳米颗粒作为一种潜在的静血剂,具有增强的性能

Chandan Bhogendra Jha^1,2, Chitrangda Singh¹, Parag Patil³

¹Division of Radiological, Nuclear and Imaging Sciences, Institute of Nuclear Medicine and Allied Sciences, DRDO, Lucknow Road, Timarpur, Delhi, India.

|November 23, 2023

概括

这项研究开发的黄金纳米颗粒 (Tr-AuNPs) 使用tranexamic酸增强血静. 在体内,Tr-AuNPs显著加快了血液凝固时间,相比单独使用胺酸.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
血液学血液学血液学

背景情况:

外部静血剂对于治疗病态出血至关重要.
特兰克萨姆酸是一种氨酸类似物,是一种已知的静血药物.
开发具有提高疗效的新型静血材料是必不可少的.

研究的目的:

合成和表征金纳米颗粒 (Tr-AuNPs) 使用tranexamic酸作为减少和封闭剂.
在体外和体内评估Tr-AuNPs的静血潜力和生物相容性.
探索Tr-AuNPs对凝血级联的协同作用.

主要方法:

使用tranexamic acid合成Tr-AuNPs. 这是一个非常好的方法.
对Tr-AuNPs的物理化学表征.
试验室凝血测定包括前列血时间 (PT),国际正常化比率 (INR) 和血栓凝结学 (TEG).
在体内静血研究和生物分布的放射性标记.
短期毒性评估. 短时间的毒性评估.

主要成果:

成功合成了Tr-AuNPs (水力动力直径~46纳米),并表现出血红相容性.
与tranexamic acid (360s) 相比,Tr-AuNPs显著减少了凝血时间 (52秒).
TEG分析显示Tr-AuNPs增强了血栓形成 (减少R和K,增加α角和MA).
放射性标记在体内证实了Tr-AuNPs的生物相容性,分布和稳定性.

结论:

与原生tranexamic acid相比,Tr-AuNPs显示出更高的静血疗效.
在纳米粒子合成中使用生物启发的分子,如特兰胺酸,为血液静止提供了协同效益.
作为有效的静血剂和潜在的治疗药物,Tr-AuNPs显示出有前途的潜力.

关键词:

氨基酸类比的氨基酸类比黄金黄金黄金黄金黄金血液静止血液静止血液静止接口接口接口接口接口纳米颗粒是一种纳米粒子.闪光摄影 (scintigraphy) 是一种闪光摄影.血小板结晶学血小板结晶学血小板结晶学

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