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拓调节的纳米催化剂用于铁化介导的癌症光疗

Guobo Chen¹, Liping Gu², Yongtian Liu²

¹Department of Anesthesiology, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China; School of Materials and Chemistry, Institute of Bismuth, Shanghai Collaborative Innovation Center of Energy Therapy for Tumors, University of Shanghai for Science and Technology, Shanghai 200093, China.

Journal of colloid and interface science

|November 23, 2023

概括

一种新的基于石的纳米光催化剂 (Bi2O3:S) 有效地诱导瘤铁亡. 这种材料产生反应性氧物种,并在近红外光下耗尽谷氨,提供了一种新的治疗策略.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

诱导铁灭的癌症疗法受到缺乏有效的单组分诱导剂的限制.
开发可激活的多功能纳米诱导剂对于推进铁质中介瘤治疗至关重要.

研究的目的:

合成和评估一种新的基于石的半导体纳米光催化剂 (Bi2O3:S) 用于向瘤铁灭疗法.
研究Bi2O3:S在近红外光照射下诱导铁亡的机制.

主要方法:

硫 bismuth氧化物 (Bi2O3:S) 纳米颗粒的拓合成.
在近红外光下对反应性氧物种 (ROS) 生成的光催化活性的评估.
评估谷氨 (GSH) 摄入量及其在氧化应激中的作用.
对木离子释放的分析及其与GSH的协同效应.
通过监测谷氨过氧化酶4 (GPX4) 表达的方法,研究铁灭菌诱导.
对光热转换效率的评估.

主要成果:

生物2O3:S纳米粒子在近红外光照射时有效地产生ROS和消耗GSH.
在酸性瘤微环境中释放的石离子放大了氧化应激,促进了生物降解.
纳米光催化剂有效降低了GPX4表达的调节,这是铁亡的一个关键标志物.
硫注射增强了近红外光诱导的光热转换,提高了治疗疗效.

结论:

开发的Bi2O3:S纳米光催化剂代表了一种有前途的单组分剂,用于光激活性铁灭菌疗法.
石离子,光生成孔和光热效应的协同作用驱动了高效的铁灭诱导.
这种纳米平台为增强瘤治疗结果提供了一个新的策略.

关键词:

比斯穆特 (Bismuth) 是一种天然矿物.铁性化 (ferroptosis) 是一种穿孔疗法是一种治疗方法.光催化疗法是一种光催化疗法.拓学综合拓学综合

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