一个与新型冠状病毒病 (COVID-19) 相关的肝脏病理病的病例控制尸检系列
Fabiola A Righi1, Richard S Vander Heide2, Rondell P Graham1
1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States of America.
Annals of diagnostic pathology
|November 23, 2023
概括
COVID-19 (冠状病毒疾病2019) 可能会导致肝损伤,尸检研究显示患者的轻度炎症和脂肪瘤. 在肝脏组织中很少检测到SARS-CoV-2RNA,这表明了二次损伤机制.
科学领域:
- 病理学 病理学 病理学
- 病毒学 病毒学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 导致COVID-19,通常与肺部问题有关,但也与肝脏功能障碍有关.
- 由于SARS-CoV-2引起的肝损伤的确切机制尚不清楚.
- 这项研究旨在与对照组相比,在已故的COVID-19患者中表征肝病理.
研究的目的:
- 为了调查和比较已故COVID-19患者的肝脏病理与非COVID-19对照.
- 为了确定与SARS-CoV-2相关的肝损伤的潜在机制.
主要方法:
- 审查了COVID-19阳性和阴性个体的尸检病例.
- 肝脏组织的组织病理学检查包括H&E染色和免疫组织化学 (CD68,ACE2).
- 滴滴数字PCR (ddPCR) 用于检测肝脏组织中的SARS-CoV-2RNA.
主要成果:
- 该研究包括48名COVID-19阳性和40名对照患者.
- 除了酒患者外,COVID-19患者的肥胖症和叶片炎症的发病率显著更高.
- 在测试的COVID-19阳性病例中的11.1%的肝脏组织中检测到SARS-CoV-2RNA.
结论:
- 在COVID-19患者中,轻微的叶片炎症和肥胖症是肝脏的主要发现.
- 在COVID-19患者中常见的类固醇疗法可能会导致肥胖症.
- 肝组织中病毒RNA的低发病率表明,COVID-19相关的肝损伤可能是次要的.
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