优化了基于ROS的纳米动力学疗法的策略,用于瘤治疗
Yifan Di1, Ruizhu Deng1, Zhu Liu1
1Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning Province 110016, China.
Biomaterials
|November 23, 2023
概括
基于反应性氧物种 (ROS) 的纳米动力疗法 (NDT) 对癌症治疗具有前景. 本综述探讨了增强ROS产生的策略,克服瘤微环境的挑战,以提高治疗疗效.
科学领域:
- 在瘤学瘤学.
- 纳米医学是一种纳米医学.
- 生物化学 生物化学
背景情况:
- 反应性氧物种 (ROS) 是瘤进展和生物过程的关键调节者.
- 基于ROS的纳米动力疗法 (NDT) 提供非侵入性,瘤特异性癌症治疗,副作用低.
- 由于复杂的瘤微环境和敏感剂限制,现有的NDT面临局限性,影响ROS水平和治疗结果.
研究的目的:
- 综合审查纳米动力学强化策略,以提高ROS在NDT中的水平.
- 为各种NDT模式概述当前的挑战和解决方案.
- 讨论基于NDT的普遍强化策略和组合治疗.
主要方法:
- 文献综述专注于基于ROS的纳米动力学疗法.
- 分析当前的困境,并为光动力学,化学动力学和声动力学疗法提供解决方案.
- 制定NDT强化策略和组合疗法.
主要成果:
- NDT是一个快速发展的领域,具有各种各样的分支,如光动力学,化学动力学和声动力学疗法.
- 提高ROS收益率的策略对于克服NDT的局限性至关重要.
- 全面强化策略和组合治疗为NDT的进步提供了有前途的途径.
结论:
- 解决瘤微环境的复杂性和敏感剂的局限性是提高NDT疗效的关键.
- 开发增强ROS生产的战略是NDT进步的迫切需要.
- 进一步的研究和临床翻译对于NDT的成功发展至关重要.
相关概念视频
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K