肺移植前内镜肺体积减小没有增加术后的肺部并发症
Anastasiya Kornyeva1, Axel Semmelmann2, Ecem Deniz Ogutur1
1Department of Thoracic Surgery, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
Respiration; international review of thoracic diseases
|November 23, 2023
概括
在肺复发性肺病患者中,移植前内镜肺体积减小 (eLVR) 不会增加肺移植 (LTx) 后并发症风险或降低存活率. 这种程序可以有效地将患者连接到LTx.
科学领域:
- 肺部病理学 肺部病理学
- 胸部外科手术 胸部外科手术
- 移植医学 移植医学
背景情况:
- 肺移植 (LTx) 是末期肺病的唯一选择.
- 与手术方法相比,移植前内镜肺体积减小 (eLVR) 数据有限.
- 调查eLVR对术后肺部并发症 (PPCs) 的影响对于肺气的LTx后至关重要.
研究的目的:
- 评估LTx后PPCs的风险,在与eLVR.桥接的肺气血病患者中.
- 为了比较在LTx之前接受eLVR的患者和没有接受eLVR的患者之间的结果.
主要方法:
- 追溯评估82名患有肺复杂性肺病的患者进行了双重肺移植 (DLTx).
- 在28名LTx前ELVR患者和54名对照患者之间对28名患者的结局进行比较.
- 使用SPSS和GraphPad Prism软件进行统计分析.
主要成果:
- 在DLTx中,eLVR患者的年龄较大 (中位数为60岁与58岁).
- 两组之间90天或长期存活率没有显著差异 (eLVR: 92/88/77%与对照: 89/77/67%在1/5/10年).
- 在两组中,PPC (OR 0.7) 和重大术后并发症的几率相似.
结论:
- eLVR不会增加PPC,手术并发症或LTx后生存率降低的风险.
- eLVR是一种安全有效的桥梁到移植策略,用于肺瘤性肺病.
- 肺炎和ARDS是LTx后长期存活率降低的独立风险因素.
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