泌尿带中一个富含原蛋白的弧形协调细胞的成型和多组织的延伸
Hongzhe Peng1, Jinghan Qiao1, Guilin Wang1
1Fang Zongxi Center, MoE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China.
Current biology : CB
|November 23, 2023
概括
一种新的类似脊椎的原结构指导着记节管的发育,并协调Ciona幼虫的尾巴组织延长. 这种细胞外基质支架对于细胞的排列和在发育过程中的比例生长至关重要.
科学领域:
- 发展生物学 发展生物学
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 细胞和组织重塑对于3D模式形成至关重要,需要通过细胞间通信精确调节细胞大小和形状.
- 在组织形态发生过程中信号传递和运输的机制仍然不完全理解.
研究的目的:
- 识别和描述参与协调组织形态发生的新型细胞外矩阵 (ECM) 结构.
- 阐明ECM在心弦发展中的作用及其与周围组织的相互作用.
主要方法:
- 使用显微镜识别Ciona幼虫尾巴中的ECM结构.
- 使用光漂白后光恢复 (FRAP) 分析原分泌和ECM形成.
- 功能性研究涉及原倒置和功能丧失实验.
主要成果:
- 一个类似于脊椎的细胞外矩阵 (ECM) 结构,主要由新形成的原体组成,被确定围绕着记节.
- 模拟了尾部组织中的原流和限制,揭示了ECM的结构形成.
- 原ECM对于心弦细胞的排列和延长至关重要;其破坏会损害心弦细胞的生长.
- ECM充当了支架,协调了表皮生长与表皮带延长,确保了比例的组织重塑.
结论:
- 笔记带积极塑造其周围的ECM,调节其自身的形态发生.
- 富含原蛋白的ECM作为信号传输和协调组织延长的关键支架.
- 这项研究揭示了一种通过ECM介导的沟通来编排组织水平形态发生的新机制.
相关概念视频
Collagens are the Major Structural Proteins of ECM
4.3K
Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
Connective tissue proper includes loose...
4.3K
Fibril-associated Collagen
2.5K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
2.5K
Structural Protein Function
27.7K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
27.7K
Growth of Cartilage and Bone Tissue
3.4K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.4K
Neurulation
42.0K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
42.0K
Cell-matrix's Response to Mechanical Forces
2.6K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...
Anchoring junctions mechanically attach a cell to the...
2.6K


