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影响重复植入失败的妇女持续怀孕率的因素,这些妇女接受了子宫内膜受体阵列测试

Hyun Kyoung Lee¹, Kyoung Yong Moon¹, Haerin Paik²

¹iORA Fertility Clinic, Suwon, Republic of Korea.

Clinical and experimental reproductive medicine

|November 23, 2023

概括

个性化胚胎移植 (pET) 后与子宫内膜受体阵列 (ERA) 进行的持续怀孕与较年轻的孕产妇年龄和更高的母细胞质量有关. 这些因素对于重复植入失败 (RIF) 的妇女的成功结果至关重要.

科学领域:

生殖医学生殖医学
基因组学就是基因组学.
胚胎学胚胎学

背景情况:

重复植入失败 (RIF) 是辅助生殖技术 (ART) 的一个重大挑战.
子宫内膜受体数组 (ERA) 是一种用于个性化胚胎移植时间的诊断工具.
了解影响RIF患者经过ERA怀孕率的因素对于改善ART成功至关重要.

研究的目的:

分析影响RIF妇女正在进行与ERA的胚胎移植的持续妊娠率 (PR) 的因素.
在这个患者群体中确定成功怀孕结果的关键预测因素.

主要方法:

在2020年6月至2022年4月期间,从54名RIF妇女获得83个个性化胚胎移植 (pET) 的回顾性分析.
玻璃化胚胎细胞转移时间以ERA结果为指导.
使用后勤回归分析来确定重要的影响因素.

主要成果:

每个pET的持续PR为33.7%.
子宫内膜受体性阶段 (受体前,早期受体,受体) 并没有显著影响PR.
较年轻的母亲年龄在第一次pET和更高的胚胎细胞质量 (得分>18) 与正在进行的怀孕有显著联系.

结论:

在使用子宫内膜受体阵列 (ERA) 的个性化胚胎移植 (pET) 中,正在进行的怀孕与较年轻的母亲年龄和优越的母细胞质量密切相关.
这些发现强调了患者年龄和胚胎选择在优化RIF妇女怀孕结果方面的重要性.

关键词:

胚胎囊中的胚胎细胞.胚胎转移胚胎转移是什么?子宫内膜 (Endometrium) 是一个内膜.怀孕怀孕怀孕怀孕接收能力接收能力

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