易挥发性有机化合物暴露与美国成年人抑郁症相关:NHANES 2011-2020年的结果
Liwei Tang1, Min Liu2, Jing Tian1
1Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, 518055, China.
Chemosphere
|November 23, 2023
概括
暴露于挥发性有机化合物 (VOC) 与抑郁症有关. 在患有抑郁症的人群中发现了尿液中较高水平的VOC代谢物,这突显了空气污染对心理健康的风险.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 挥发性有机化合物 (VOC) 导致空气污染,已知是神经毒素.
- 抑郁症是一个重要的全球心理健康问题,具有复杂的病因.
- 挥发性有机化合物暴露与抑郁症之间的具体联系仍未得到充分研究.
研究的目的:
- 调查尿液挥发性有机化合物代谢物 (mVOCs) 与成人抑郁症状之间的关联.
- 探索mVOCs对抑郁风险的单一和混合影响.
- 为了确定有助于抑郁风险的特定VOC.
主要方法:
- 利用了国家健康和营养检查调查中5676名成年人的数据.
- 通过二进制物流和受限制的立方脊柱回归分析了15个主要的尿路mVOC成分.
- 在混合物分析中使用加权量子素和和最小绝对收缩和选择操作员回归.
主要成果:
- 在抑郁症组中观察到15种尿路mVOC中的11种度升高.
- 十二种mVOC成分与抑郁症状有显著的积极关联.
- 确定了五种主要的mVOC (URXCYM,URXPHG,URX34 M,URXMB3,URXAMC) 是主要的贡献者.
结论:
- 尿液中的mVOCs作为VOC暴露的生物标志物,并且与抑郁症有显著的关联.
- 暴露于特定的VOC如烯,烯,烯,烯,烯,1,3-丁和烯可能会增加抑郁症的风险.
- 需要更加关注VOC暴露对心理健康的影响.
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