从COVID-19中康复后的长期胃肠道表现
B Joseph Elmunzer1, Olafur S Palsson2, Nauzer Forbes3
1Division of Gastroenterology and Hepatology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.
概括
住院的COVID-19幸存者经常经历长期的胃肠道 (GI) 问题和肠-大脑相互作用 (DGBI) 障碍. 最初的胃肠道症状的严重程度和心理创伤显著预测COVID-19后持续的胃肠道问题.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- COVID-19,主要是一种呼吸系统疾病,表现出显著的胃肠道 (GI) 热带.
- 已知急性肠道感染会导致长期的胃肠道疾病.
- 患有COVID-19的住院治疗可能会使个人容易出现长时间的肠道表现.
研究的目的:
- 调查COVID-19住院治疗的长期胃肠道影响.
- 评估持续的胃肠道症状和COVID-19幸存者的肠-大脑相互作用 (DGBI) 障碍的发展.
- 为了确定与GI症状严重程度和COVID-19后DGBI发展相关的因素.
主要方法:
- 在住院12-18个月后对530名COVID-19幸存者进行了后续调查.
- 调查工具包括DGBI的罗马四号诊断问卷,COVID相关症状尺度和创伤症状问卷.
- 回归分析探讨了随访时胃肠道症状严重程度的预测因素.
主要成果:
- 60.3%的受访者满足了至少一个罗马四号DGBI的标准,比美国一般人口更高的流行率.
- 在住院期间出现胃肠道症状的患者中,42.1%在随访时保持了症状.
- 较高的初始胃肠道症状严重程度和心理创伤 (PTSD) 与持续的胃肠道症状和DGBI患病率密切相关.
结论:
- 患有COVID-19的住院治疗与DGBIs的高患病率和12-18个月后持续的GI症状有关.
- 在急性COVID-19疾病期间,胃肠道症状的严重程度和心理创伤的程度是长期胃肠道问题的重要预测因素.
- 研究结果强调需要对COVID-19幸存者的胃肠道和心理后果进行全面评估和管理.
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