相关实验视频
Updated: Jul 10, 2025

09:10
Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
Published on: July 27, 2022
2.2K
微生物群在辐射引起的小肠损伤中的作用
Yi-Fan Chen1,2, Sung-Chou Li3, Eng-Yen Huang1,4
1Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 129, Da-Pi Road, Niao-Sung District, Kaohsiung 833401, Taiwan.
Journal of radiation research
|November 23, 2023
概括
来自抗辐射小鼠的肠道细菌可以防止肠道受损. 将这些微生物移植到野生型小鼠中,在暴露于辐射后改善了小肠道密室的存活率.
科学领域:
- 微生物学 微生物学
- 辐射生物学 辐射生物学
- 胃肠病学 胃肠病学
背景情况:
- 辐射暴露可能导致急性辐射综合征,特别是损害胃肠道.
- 加勒-1和互白素-6 (IL-6) 与肠道抗辐射和小损伤有关.
- 肠道细菌在减轻辐射引起的肠道损伤中的作用需要进一步研究.
研究的目的:
- 为了确定由galectin-1或IL-6调节的肠道细菌是否可以减少辐射诱导的小肠损伤.
- 分析特定细菌种群和Firmicutes/Bacteroidetes (F/B) 比率对肠道抗辐射的影响.
- 评估抗辐射肠道菌群在减轻辐射损伤方面的治疗潜力.
主要方法:
- 微生物组阵列分析在加列-1淘汰赛,sgp130转基因和野生类型 (WT) 小鼠上进行.
- 进行全腹部辐射 (18 Gy),以评估对细菌族群和F/B比率的影响.
- 从耐辐射小鼠移植便微生物群到WT小鼠,然后进行免疫组织化学检查以量化存活的肠道密室.
主要成果:
- 从galectin-1淘汰赛和sgp130转基因小鼠的便移植显著增加了WT小鼠在辐射后的小肠密室的存活率.
- 观察到的辐射电阻独立于F/B比率.
- 接受抗辐射便细菌的WT小鼠在暴露于辐射后改善了小肠小的修复.
结论:
- 肠道细菌在减轻辐射诱导的小肠损伤方面发挥着至关重要的作用.
- 影响加勒-1或IL-6通路的基因调节可以通过肠道微生物群调节赋予放射电阻.
- 对特定的抗辐射细菌菌株进行进一步的研究是有必要的,用于临床应用,以减轻放射治疗的副作用.
相关概念视频
Bacterial Flora of the Large Intestine
473
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
473
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
337
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
337
Anatomy of the Intestines
72.1K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.1K

