在瘤生长的多相移动边界模型中,模式形成和移动波
Jacob M Jepson1, Reuben D O'Dea1, John Billingham1
1School of Mathematical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
Mathematical medicine and biology : a journal of the IMA
|November 23, 2023
概括
这项研究分析了瘤生长的数学模型,揭示了细胞分布模式或移动波的条件,表明瘤扩张或收缩. 最初的条件和细胞流体相互作用会影响这些结果.
科学领域:
- 数学生物学 数学生物学
- 计算生物学 计算生物学
- 瘤动力学 瘤动力学
背景情况:
- 瘤生长涉及癌细胞和细胞外环境之间的复杂相互作用.
- 数学模型对于理解瘤进化和扩散的动态至关重要.
研究的目的:
- 分析多相,移动的瘤细胞进化的边界模型的移动波和模式形成行为.
- 确定控制瘤生长,灭绝和细胞分布模式的形成的标准.
主要方法:
- 利用一个多相,移动的边界模型,包括两个部分微分方程.
- 执行数值模拟以观察解决方案.
- 进行旅行波和稳定性分析以确定波速和模式形成标准.
主要成果:
- 确定了导致具有高和低细胞密度区域的模式解决方案的条件.
- 证明了与瘤生长 (前进波) 或灭绝 (后退波) 相对应的移动波解决方案.
- 导出了瘤生长/灭绝的标准,以及基于模型参数的模式解决方案的出现.
结论:
- 该模型准确地预测了瘤细胞分布中的均移动波和复杂的空间模式.
- 最初的细胞分布,细胞运动和细胞液体阻力显著影响由此产生的瘤形态和动态.
相关概念视频
Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
Metastasis
5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
Travelling Waves
5.2K
A wave is a disturbance that propagates from its source, repeating itself periodically, and is typically associated with simple harmonic motion. Mechanical waves are governed by Newton's laws and require a medium to travel. A medium is a substance in which a mechanical wave propagates, and the medium produces an elastic restoring force when it is deformed.
Water waves, sound waves, and seismic waves are some examples of mechanical waves. For water waves, the wave propagation medium is...
Water waves, sound waves, and seismic waves are some examples of mechanical waves. For water waves, the wave propagation medium is...
5.2K
Propagation of Waves
2.3K
When a wave propagates from one medium to another, part of it may get reflected in the first medium, and part of it may get transmitted to the second medium. In such a case, the interface of the two mediums can be considered as a boundary that is neither fixed nor free.
Consider a scenario where a wave propagates from a string of low linear mass density to a string of high linear mass density. In such a case, the reflected wave is out of phase with respect to the incident wave, however the...
Consider a scenario where a wave propagates from a string of low linear mass density to a string of high linear mass density. In such a case, the reflected wave is out of phase with respect to the incident wave, however the...
2.3K
Cell Migration
4.9K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
4.9K
Traveling Waves: Lossless Lines
140
The provided content explores the behavior of traveling waves on single-phase lossless transmission lines. It begins with a single-phase two-wire lossless transmission line of length Δx, characterized by a loop inductance LH/m and a line-to-line capacitance C F/m. These parameters result in a series inductance LΔx and a shunt capacitance CΔx.
140


