性二态和灵长类动物基因组中的雄激素反应元素扩散之间的关系
Andrew P Anderson1, Adam Jones2
1Department of Biology, Reed College, Portland, OR, United States.
Evolution; international journal of organic evolution
|November 23, 2023
概括
性选择通过雄激素反应元素 (ARE) 驱动男性特征的进化. 全基因组ARE数量与灵长类动物 (包括人类) 的性选择强度和雄性基因表达相关.
科学领域:
- 进化生物学是进化的生物学.
- 基因组学就是基因组学.
- 生殖生物学 生殖生物学
背景情况:
- 性选择影响了许多脊椎动物雄性中性二态特征的演化.
- 由雄激素反应元素 (ARE) 介导的雄激素信号传递在这些特征的发展中起着关键作用.
- 在AREs的基因组位置和数量的变化可以改变基因调节和表达模式.
研究的目的:
- 研究基因组范围内的雄激素反应元素 (ARE) 数量与灵长类动物的性选择强度之间的关系.
- 确定ARE分布和数量是否与男性偏向的基因表达和性变态有关.
主要方法:
- 对最近测序的灵长类动物基因组进行分析.
- 比较基因组学以识别AREs及其相对于基因的位置.
- 对ARE数量,基因表达模式和性选择指标 (例如,犬体大小变异) 之间的相关性分析.
主要成果:
- 与随机基因组区域相比,人类在男性偏差和雄激素敏感基因附近的ARE频率更高.
- 在灵长类动物中,ARE的增加或减少与改变的男性基因表达和性别偏差表达水平相关.
- 在灵长类动物中,增加犬体大小的性二态性与更高的全基因组ARE计数有关.
结论:
- 灵长类基因组中雄激素反应元素 (ARE) 的数量和分布受性选择的影响.
- 包括人类在内的灵长类基因组中的雄激素反应是由男性与男性竞争交配机会而形成的.
- AREs是关键的基因组元素,调解了性选择对男性特征的进化影响.
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