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在使用Atellica® IM Solution 免疫测试分析仪的加泰罗尼亚妇女中,甲状腺激素在第一季度的参考范围
Marina Giralt1, Noelia Díaz-Troyano1, Immaculada Comas1
1Department of Biochemistry, Vall d'Hebron University Hospital, Barcelona, Spain.
Annals of clinical biochemistry
|November 23, 2023
概括
这项研究确定了巴塞罗那孕妇甲状腺刺激激素 (TSH) 和自由甲状腺素 (FT4) 的第一季度参考范围. 这些发现为诊断妊娠性甲状腺功能低下症并确保最佳的孕产妇和胎儿健康提供了关键数据.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 临床化学 临床化学
背景情况:
- 孕期甲状腺功能低下症与不良的怀孕和孩子的结果有关.
- 在怀孕期间,甲状腺激素水平自然会波动,特别是在头三个月.
- 建立准确的参考范围对于及时诊断和管理至关重要.
研究的目的:
- 在巴塞罗那的孕妇中确定TSH和FT4的第一季度参考范围.
- 为临床实践和妊娠内分泌学研究提供必要的数据.
主要方法:
- 一项前性研究,涉及673名怀孕妇女在他们的第一个三个月 (8-13周怀孕).
- 使用Atellica® IM 1600平台测量血清TSH,FT4和TPOAb的水平.
- 在排除了418名女性后,计算了参考范围 (2.5至97.5百分位数),分析了年龄,BMI,种族,和吸烟等因素.
主要成果:
- 确立的第一季度参考范围:TSH 0.1114.291 mIU/L和FT4 11.4517.76 pmol/L.
- 根据母亲的年龄,补充剂或吸烟习惯,甲状腺激素水平没有显著差异.
- 在TPOAb的流行率为10.0%.
结论:
- 在这组人群中,妊娠第一季度的最佳TSH上限是4.3mIU/L.
- 这一发现与ATA-2017指南建议的4.0mIU/L一致.
- 这些参考范围有助于在怀孕早期准确诊断甲状腺功能障碍.
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