细胞因子武装的树突细胞原始体用于抗原无关的癌症免疫疗法
Ali Ghasemi1,2,3, Amaia Martinez-Usatorre1,2,3, Luqing Li1,2,3
1Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL), Lausanne, Switzerland.
Nature cancer
|November 23, 2023
概括
工程造型的树突细胞原始细胞 (DCPs) 生产IL-12和FLT3L细胞因子抑制了瘤的生长. 这种新型细胞疗法在癌症治疗方面表现有前途,增强免疫反应并与其他疗法协同.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞疗法细胞疗法
- 在瘤学瘤学.
背景情况:
- 树突细胞 (DCs) 对于T细胞在癌症免疫中的调节至关重要.
- 以前使用抗原脉冲单细胞衍生的DCs的DC基癌症疫苗产生了混合的临床结果.
- 需要更有效的基于直流的免疫疗法.
研究的目的:
- 开发一种新的细胞治疗平台,使用工程 dendritic 细胞原生体 (DCPs).
- 为了评估细胞因子武装的DCPs在抑制瘤生长中的有效性.
- 探索DCP在组合疗法中的潜力.
主要方法:
- 工程小鼠或人类的DCP产生免疫刺激性细胞因子IL-12和FLT3L.
- 向携带瘤的小鼠模型 (黑色素瘤,肝脏,质瘤) 给予细胞因子武装的DCP.
- 评估瘤生长抑制,免疫细胞透,激活和巨细胞编程.
主要成果:
- 细胞因子武装的DCPs分化为cDC1并抑制瘤生长,而无需抗原加载.
- 瘤抑制是IL-12和FLT3L协同作用的结果,促进NK和T细胞透和M1-类巨细胞.
- DCPs增强了依赖内源cDC1和IFN-γ的抗瘤免疫力,并与抗质瘤的CAR T细胞协同作用.
结论:
- 工程化细胞因子武装的DCPs代表了癌症治疗的强大细胞治疗平台.
- 这种方法有效地利用了对瘤的先天性和适应性免疫反应.
- DCPs在瘤学中具有重要的组合免疫疗法的潜力.
相关概念视频
01:27Tumor Immunotherapy
530
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
530
01:30Cancer Vaccines
376
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
376
01:27Cytotoxic T Cells-mediated Immune Response
924
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
924