环境空气污染物和发生结石之间的积极联系
Xiaoqin Gan1, Yanjun Zhang1, Panpan He1
1Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510515, China.
Environmental science and pollution research international
|November 23, 2023
概括
暴露于空气污染,包括细颗粒物 (PM2.5) 和二氧化 (NO2),与患结石的风险增加有关. 改善空气质量对于脏健康至关重要.
科学领域:
- 环境流行病学环境流行病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
背景情况:
- 结石是一种普遍的疾病,对健康和经济造成重大负担.
- 空气污染是一个日益关注的问题,与各种呼吸道和心血管疾病有着确定的联系.
- 空气污染物对结石发病率的影响仍然不太清楚.
研究的目的:
- 调查暴露于特定空气污染物和患结石风险之间的关联.
- 为了检查多种空气污染物对石发病率的综合影响.
- 探索遗传敏感性是否会改变空气污染和结石之间的关系.
主要方法:
- 分析了来自英国生物银行的一项大型队列研究 (453,977名参与者),没有先前的结石.
- 使用土地利用回归模型估计了对PM2.5,PM2.5-10,PM10,NO2和NOx的暴露.
- 计算了对空气污染的加权评分和对结石的遗传风险评分 (GRS). 突发性结石是主要结果,随访时间中位数为11.9年.
主要成果:
- 增加对PM2.5,PM10,NO2和NOx的暴露与发生结石的风险更高有关 (HRs在1.02至1.05之间).
- 在加权空气污染评分和结石风险之间观察到线性关联.
- 这种关联在没有糖尿病的个体中更为明显,并且在患有中高基因结石风险得分的人群中呈现显著的趋势.
结论:
- 暴露于常见的空气污染物与发生结石的风险增加有关.
- 改善空气质量的措施可能有助于预防结石.
- 需要进一步的研究来阐明遗传倾向在与空气污染相关的结石发育中的作用.
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