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眼睛中的帕拉帕皮勒胆道微血管液滴落,具有初级开角玻璃眼病

Ryoko Igarashi¹, Shun Ochiai², Tadamichi Akagi²

¹Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachido-ri, Chuo-ku, Niigata, 951-8510, Japan. iryoko@med.niigata-u.ac.jp.

Scientific reports

|November 23, 2023

概括

青光眼患者的微血管流失 (MvD) 区域与结构性视神经损伤相关. 这一发现表明,MvD区域可以表明青光眼的严重程度和相关的血管变化.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
玻璃眼研究研究玻璃眼研究

背景情况:

主要开角青光眼 (POAG) 是不可逆转失明的主要原因.
微血管脱落 (MvD) 是一种在青光眼中观察到的病理特征.
光学连贯断层扫描血管造影 (OCTA) 允许对视网膜血管系统进行非侵入性可视化.

研究的目的:

调查POAG.患者的微血管流失 (MvD) 区域和各种临床参数之间的关系.
为了确定MvD区域是否可以作为青光眼严重程度的生物标志物.

主要方法:

在55名POAG患者中,OCTA被用于测量MvD区域和周周状胆道缩 (PPA) 区域.
评估了环囊神经纤维层 (cpRNFL) 厚度,光盘参数和汉弗里场分析仪 (HFA) 视野指数 (MD,PSD).
使用Spearman的等级相关系数来分析MvD面积和其他参数之间的关系.

主要成果:

平均MvD面积为0.18 ± 0.17 mm2,平均PPA面积为1.13 ± 0.72 mm2. 平均PPA面积为1.13 ± 0.72 mm2. 平均PPA面积为1.13 ± 0.72 mm2.
MvD区域与光盘边缘区域 (p=0.0017),cpRNFL厚度 (p=0.0027),HFA 24/10-2 MD和PSD (p<0.001) 有显著的相关性.

结论:

在POAG中,MvD区域与结构和功能参数显著相关.
MvD区域可以作为青光眼严重程度的指标,并反映出周围毛囊血管结构的变化.

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