在妊娠高血压疾病中的血脑屏障功能障碍
Simranjit Kaur1, Hadley T Ewing1, Junie P Warrington2
1Department of Neurology, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Current hypertension reports
|November 23, 2023
概括
妊娠高血压障碍 (HDP) 可以破坏血脑屏障 (BBB),导致大脑并发症. 需要进一步的研究来了解HDP.
科学领域:
- 产科和妇科 产科和妇科
- 神经学 神经学
- 心血管研究研究心血管研究
背景情况:
- 在过去的二十年中,妊娠高血压疾病 (HDP),特别是孕前的发病率显著增加.
- 大脑和视觉症状在HDP患者中很常见,并且在与新发性高血压相结合时,可以成为孕前的诊断标准.
- 新出现的证据将HDP中的脑部并发症与受损的血脑屏障 (BBB) 联系起来.
研究的目的:
- 在妊娠高血压疾病 (HDP) 的背景下,审查目前关于血脑屏障 (BBB) 的文献.
- 确定有关HDP和BBB相互作用的现有知识差距.
- 在这个专业领域提出未来的研究方向.
主要方法:
- 对最近研究的文献综述,重点关注妊娠高血压障碍 (HDP) 中的血脑屏障 (BBB).
- 分析与孕前相关的发现及其对大脑血管系统的影响.
- 在动物和临床研究中确定研究需求.
主要成果:
- 大多数关于HDPBBB变化的研究都集中在产前症上.
- 在HDP中,高血压与周围血管巨细胞/微细胞的增加,循环细胞外囊泡的升高和脑血流自调节的减少有关.
- 对动物模型有很大的需求,以探索BBB保护策略,并预防HDP的脑血管问题.
结论:
- 进一步的临床研究对于阐明不同HDP亚型,BBB完整性和认知功能之间的短期和长期关系至关重要.
- 保护BBB是预防HDP神经复杂症的关键目标.
- 解决HDP发病率上升的问题需要对其神经系统基础有更深入的了解.
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