在发育性阅读障碍症中,表面形态和结构共变网络的非典型特征变化
Yusi Zhang1,2,3,4, Jiayang Huang1,2, Li Huang1,2
1National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.
概括
发育性阅读障碍 (DD) 与明显的大脑结构差异有关. 患有DD的儿童在关键的额头区域表现出改变的皮质折叠和连接,影响阅读和拼写能力.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 认知科学 认知科学
背景情况:
- 发育性阅读障碍 (DD) 是一种神经发育障碍,其特点是阅读和拼写困难.
- 对于DD的精确神经支仍然不完全理解.
研究的目的:
- 研究与典型发育 (TD) 儿童相比,DD和孤立拼写障碍 (SpD) 的儿童的大脑表面形态和结构连接的差异.
- 探索DD中信息处理缺陷的神经基础.
主要方法:
- 在TD,SpD和DD组中比较皮质厚度,折叠指数和布罗卡区域 (左下额头 - IFGtriang和部部分) 的平均曲率.
- 分析了左IFG三角形的结构共变网络 (SCN),以评估SpD和DD组中的结构连接性变化.
主要成果:
- 与TD和SPD组相比,DD儿童在左IFG三角形中表现出皮层曲率和折叠的增加.
- 在DD组中,左IFG三角形和左中前回形/右中轨道前回形之间的结构连接性增加.
- 在DD组中,左IFGtriang和右前/前带肌之间观察到结构连接性下降.
结论:
- 发育性阅读障碍与大脑区域的非典型结构连接有关,这些区域对视觉注意力和记忆至关重要.
- 这些DD的连接性变化可能会损害阅读和拼写学习所需的信息输入和集成.
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