在雄性和雌性中,皮质otropin释放因子-多巴胺相互作用:超出了经典的VTA
E A Kelly1, T M Love2, J L Fudge1,3
1Departments of Neuroscience, Del Monte Institute of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Synapse (New York, N.Y.)
|November 24, 2023
概括
皮质otropin释放因子 (CRF) 主要影响多巴胺 (DA) 系统调节间接地通过准灵长类动物的偏脊椎色素核和后脑野中的非多巴胺神经元.
科学领域:
- 神经科学是一个神经科学.
- 神经内分泌学神经内分泌学
- 细胞生物学 细胞生物学
背景情况:
- 多巴胺 (DA) 与压力和精神疾病有关.
- 皮质otropin释放因子 (CRF) 是一个关键的应激反应调解者.
- CRF向腹部中脑的多巴胺系统,包括非DA细胞.
研究的目的:
- 在灵长类PBP和A8区域中,对DA和非DA细胞上的CRF标记的突触终端进行表征.
- 为了研究CRF突触组织中的性别差异.
- 为了评估基线荷尔蒙变异性.
主要方法:
- 免疫反应性电子显微镜 (EM) 在雄性和雌性.
- 在氨酸氧酶 (TH) +和TH-细胞上标记CRF的突触终端的表征.
- 在6个月的时间内进行荷尔蒙测试 (皮质醇).
主要成果:
- 在PBP和A8.8.中,CRF终端主要与非DA (TH-) 树突接触.
- 对称 (假定抑制) 的TH-树突上的CRF突触比不对称 (假定刺激) 的CRF突触更丰富.
- 在男性和女性中,整体模式是相似的,区域性性别特异性差异.
结论:
- 在基线时,CRF通过非DA神经元间接调节灵长类PBP和A8多巴胺系统.
- 这种间接调节途径在两性之间保持不变,但存在一些区域差异.
- 在研究期间,最低的基线皮质醇变化表明稳定的荷尔蒙状况.
关键词:
(A8) 一个8) A8) 一个皮质类药物 皮质类药多巴胺是多巴胺的一种.电子显微镜的电子显微镜非人类灵长类的灵长类.副手臂核 (PBP) 是一个脑后脑膜领域 (RRF)腹部顶部区域 (VTA) 的情况.更多相关视频
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