在有或没有创伤后应激障碍的退伍军人中,军事暴露和海湾战争疾病
Stephen H Boyle1, Julie Upchurch1, Elizabeth J Gifford1,2
1Cooperative Studies Program Epidemiology Center, Durham VA Medical Center, Durham VA Health Care System, Durham, North Carolina, USA.
Journal of traumatic stress
|November 24, 2023
概括
海湾战争疾病 (GWI) 与军事暴露和创伤后应激障碍 (PTSD) 有关. 患有GWI和PTSD的退伍军人报告了比单独患有GWI的退伍军人更多的暴露,这表明疾病发展中的组合作用.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 海湾战争疾病 (GWI) 是一种慢性多症状疾病,可能与1990-1991年海湾战争期间的神经毒剂暴露有关.
- 创伤后应激障碍 (PTSD) 经常与GWI同时发生,这表明在症状表现中可能发挥作用.
研究的目的:
- 调查自我报告的军事暴露与GWI之间的关联.
- 通过海湾战争退伍军人中PTSD的存在或不存在来分层这些协会.
主要方法:
- 使用海湾战争时代队列和生物存储库对921名海湾战争退伍军人的数据进行分析.
- 根据CDC标准确定GWI状态;参与者分为GWI,GWI+/PTSD和GWI+/PTSD+组.
- 多变量后勤回归用于评估GWI/PTSD组之间的关联和报告的军事暴露 (例如,pyridostigmine药片,农药,战斗).
主要成果:
- 与GWI+/PTSD-组相比,GWI+/PTSD+组报告大多数军事暴露的几率明显更高.
- 此外,GWI+/PTSD组报告军事暴露的几率也高于GWI组,不包括pyridostigmine药丸.
- 这些发现表明暴露水平和GWI/PTSD状态之间存在剂量反应关系.
结论:
- 无论是PTSD还是特定的军事暴露,似乎都在海湾战争疾病的病因学中发挥着重要作用.
- 创伤后应激障碍的同时出现加大了军事暴露和GWI症状之间的关联.
- 需要进一步的研究来阐明环境暴露和GWI病变发生过程中的心理创伤之间的复杂相互作用.
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