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儿童咳的表型:潜伏类分析
Maria Christina Mallet1,2, Eva S L Pedersen1, Ronny Makhoul1,2
1Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
概括
在儿童中发现了四种不同的咳表型,大多数病例与过敏有关. 这种分类有助于了解咳的原因,并预测儿科患者的结果.
科学领域:
- 儿科肺病学 儿科肺病学
- 临床数据科学 临床数据科学
- 过敏和免疫学 过敏和免疫学
背景情况:
- 儿科咳的表型分类对于了解潜在病因至关重要.
- 目前的方法可能无法完全捕捉儿童咳的各种表现.
- 以数据为导向的方法可以完善识别不同的咳现象型.
研究的目的:
- 通过使用统计数据驱动的方法,识别和验证儿童中不同的咳表型.
- 与临床特征,医生诊断和长期预后相关联识别的表型.
- 根据可测量的特征和过敏标志物来区分咳的表现.
主要方法:
- 隐性类分析应用于531名咳但没有当前喘息的儿童 (5-16岁) 的数据.
- 现象类型是从9个报告的症状和特征中得出的.
- 根据阿托皮病史,并发症,螺旋测量,部分呼出氧化 (FeNO),过敏测试和1年的预后,对组进行了比较.
主要成果:
- 鉴定了四种表型:非特异性咳 (26%),非过敏性传染性/夜间咳与打 (4%),慢性过敏性干燥夜间咳与打 (9%),和过敏性非传染性咳与犀牛结膜炎 (61%).
- 过敏表型显示出较高的亚托皮和喘病史,高的FeNO水平,和更积极的过敏测试.
- 随后的喘息在过敏表型组中比非特异性咳组更频繁.
结论:
- 确定了四种具有临床相关性的儿科咳表型,具有不同的预后.
- 大多数咳的儿童,即使没有当前喘息,也与与过敏相关的表型有关.
- 这种表型分类提供了对儿科咳及其管理影响的精细理解.
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