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Updated: Jul 10, 2025

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使用DepMap优先考虑癌症类型特定的治疗脆弱性的新管道将PAK2确定为头部和部状细胞癌的标

Malay K Sannigrahi1, Austin C Cao1, Pavithra Rajagopalan1

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA.

Molecular oncology
|November 24, 2023
PubMed
概括

这项研究提出了一个新的管道,用于使用CRISPR屏幕从依赖地图 (DepMap) 找到癌症药物标. 对于头部和部状细胞癌 (HNSCC),它确定了PAK2作为一个有前途的治疗标.

关键词:
克里斯普尔是什么意思?克里斯普尔是什么意思?这里有DepMapDepMap的地图.在PAK2中使用PAK2.头部和部状细胞癌瘤有针对性的治疗.野生类型的p53

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