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骨肌肉量与发病糖尿病之间的性别特定关联:基于人口的队列研究
Dan Liu1, Nan Li2, Yiling Zhou1
1Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.
Diabetes, obesity & metabolism
|November 24, 2023
概括
预测较高的骨肌肉质量指数 (pSMI) 与女性2型糖尿病风险降低有关. 在男性中,这种关联仅对肌肉质量较低的人具有意义.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 2型糖尿病是一个日益严重的全球健康问题.
- 骨肌肉质量在新陈代谢调节中起作用.
- 了解影响糖尿病风险的因素对于预防至关重要.
研究的目的:
- 为了检查预测的骨肌肉质量指数 (pSMI) 和新发型2型糖尿病之间的关系.
- 调查这种关联中潜在的性别特异性差异.
- 为了分析一个大型的中国成年人队列中的关联.
主要方法:
- 使用WATCH数据库进行的回顾性纵向队列研究.
- 预测的骨肌肉质量指数 (pSMI) 的计算.
- 在考克斯回归中使用处罚和细分线性线条建模的非线性和零碎关联.
主要成果:
- 47,885名成年人 (53.2%是女性) 接受了5年的随访;1836人患上了2型糖尿病.
- 在女性中,较高的PSMI与较低的糖尿病风险相关 (HR 0.79 per SD).
- 在男性中,观察到非线性关联;只有当PSMI低于8.1时,更高的PSMI才能降低风险.
结论:
- 增加肌肉质量与女性2型糖尿病风险降低有关.
- 在男性中,肌肉质量与2型糖尿病风险之间的保护性关联仅在肌肉质量较低的个体中是明显的.
- 这些发现强调了肌肉质量在预防糖尿病中的重要性,并考虑了性别特异性.
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