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来自缅甸和阿富汗的片样本的地理分类通过NMR分析和化学测量

Cui-Mei Liu¹, Wei Jia¹, Xue-Yan Liu²

¹Key Laboratory of Drug Monitoring and Control, Drug Intelligence and Forensic Center of Ministry of Public Security, Beijing, China.

Drug testing and analysis

|November 24, 2023

概括

核磁共振 (NMR) 分析快速而准确地将片从缅甸和阿富汗区分开来. 这种更快的方法简化了样本准备,以便进行有效的地理分类.

科学领域:

法医科学法医科学法医科学
分析化学分析化学
化学测量化学测量化学测量

背景情况:

片的生产集中在缅甸和阿富汗等地区.
准确地确定片的地理来源对于法医和监管目的至关重要.
传统的片分析分析方法可能耗时且复杂.

研究的目的:

开发一种快速可靠的方法,根据地理来源对片样品进行歧视.
为了评估核磁共振 (NMR) 分析的有效性,与片分类的化学测量相结合.
为了提高效率,优化样品准备和分析程序.

主要方法:

使用质子核磁共振 (H-NMR) 光谱学分析了50个缅甸和46个阿富汗片样本.
用脱甲醇 (CD₃OD) 直接提取片样本,以尽量减少样本准备时间.
在化学分类中应用直角局部最小平方差分分析 (OPLS-DA).

主要成果:

1 H-NMR 分析成功地描述了片样本的化学特征.
一个简化的样本准备协议 (直接提取) 证明足以进行分类.
开发的OPLS-DA模型实现了缅甸和阿富汗片样本之间的完全歧视,并实现了100%的正确分类.
与传统技术相比,NMR方法显示了更快的分析 (不到3分钟) 和可重复性.

结论:

H-NMR分析与OPLS-DA相结合,为片的地理分类提供了一个快速,可重复和准确的策略.
这种方法为法医分析和药物分析提供了有价值的工具.
这项研究强调了基于NMR的化学测量技术在对复杂的自然产品进行有效分析方面的潜力.

关键词:

进行NMR分析.这是分类分类的分类.地理来源的地理来源.片片是一种片.正角部分最小平方差分分析 (OPLS-DA)

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