在使用不同的诊断标准的三个澳大利亚样本中,认知"超级衰老"的频率不同
Alice Powell1, Ben C P Lam1,2, David Foxe3
1Centre for Healthy Brain Ageing, Discipline of Psychiatry & Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
International psychogeriatrics
|November 24, 2023
概括
老年人的认知超级衰老根据定义有很大差异,影响频率和一致性. 超级衰老与更好的功能,大脑健康和降低痴呆风险有关.
科学领域:
- 老年学和认知神经科学
- 神经退行性疾病研究研究
- 老龄化和大脑健康研究研究
背景情况:
- 异常认知,或认知超衰老,在老年人群中是一种罕见的现象.
- 了解认知超衰老的患病率和特征对于衰老研究至关重要.
研究的目的:
- 用各种定义来确定澳大利亚老年人认知超衰老的频率.
- 评估不同超老化定义之间的一致性.
- 探索超级衰老状态与功能,神经成像和痴呆症发病率结果之间的关系.
主要方法:
- 对三项涉及没有痴呆症的老年人纵向队列研究的分析.
- 使用基于神经心理测试的九个不同的定义来评估超级衰老.
- 探索与功能表现,脑成像标志物和事件痴呆症的关联.
主要成果:
- 超衰老的频率在2.9%至43.4%之间,受定义严格性的影响.
- 定义之间的一致性从差到非常好各不相同.
- 超级衰老与功能改善,白质强度降低和痴呆风险降低有关.
结论:
- 认知超衰老的定义显著影响其观察到的频率和特征.
- 建立一致的定义对于准确地描述这种特殊的认知群体至关重要.
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