一种特洛伊木马的方法来增强细胞吸收酸复合物的酸复合物
Pablo Labra-Vázquez1,2, Erika Rocha2, Yue Xiao1
1Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, F-31077, Toulouse, France. pab.labra@gmail.com.
Dalton transactions (Cambridge, England : 2003)
|November 24, 2023
概括
化 (RuNO) 复合物对光激活化疗具有前景. 用17α-乙烯乙醇 (EE) 功能化RuNO复合物显著增强了细胞吸收,显示出向药物递送的潜力.
科学领域:
- 无机化学 无机化学
- 药用化学 医学化学
- 摄影化学的使用.
背景情况:
- 化 (RuNO) 复合物是可光激活的氧化 (NO ̇) 捐赠体,具有用于光激活化疗的潜力.
- 这些极性,大分子的有效细胞吸收仍然是针对药物输送的挑战.
研究的目的:
- 为了合成和表征与17α-乙乙醇 (EE) 功能化的RuNO复合体,以进行向的输送.
- 评估皮肤纤维细胞中EE功能化的RuNO复合物的细胞吸收.
主要方法:
- 合成EE功能化的RuNO复合物 (EE-Phtpy-RuNO) 和一个参考化合物 (Phtpy-RuNO).
- 合成复合物的化学,光物理和光化学特征.
- 在皮肤纤维细胞中细胞吸收的评估.
主要成果:
- 这两种复合体在水性介质中表现出类似的光学吸收和NO的释放效率.
- 与皮肤纤维细胞中的Phtpy-RuNO相比,EE-Phtpy-RuNO的细胞吸收增加了10倍.
- 这突出了EE作为分子特洛伊木马的潜力,用于定向的RuNO交付.
结论:
- 在EE部分有效地提高RuNO复合体的细胞吸收.
- 生物仿真类类固醇合物显示出针对性光激活化疗的前景.
- 对有针对性的RuNO交付系统进行进一步的研究是有必要的.
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