干果摄入量与DNA甲基化之间的关联:多变量孟德尔随机化分析
1Xiqiao Xiang. Department of PET Imaging Center, Shanghai Jiaotong University Affiliated Sixth People Hospital South Campus. Shanghai, 201499, China.
The journal of nutrition, health & aging
|November 24, 2023
概括
增加干果摄入量与生物衰老的减缓有关,特别是减少了GrimAge加速和PhenoAge加速. 这表明,干果可能会促进长寿和更健康的衰老.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 营养流行病学 营养流行病学
- 遗传学 是一个遗传学.
背景情况:
- 观察性研究表明,干果消费与DNA甲基化 (DNAm) 之间存在联系.
- 然而,观测设计容易产生混和反向因果关系,质疑这种关联的因果性.
研究的目的:
- 使用孟德尔随机化研究干果摄入量与DNA甲基化之间的因果关系.
- 评估干果消费对表观遗传衰老标志物的影响.
主要方法:
- 使用IEU开放GWAS数据库进行双样本门德尔随机化 (MR) 分析.
- 选择与干果摄入相关的43个单核酸多态 (SNPs) 作为仪器变量.
- 分析DNAm结果,包括GrimAge加速 (AgeAccelGrim) 和PhenoAge加速 (AgeAccelPheno),使用MR-Egger和加权中位数方法进行敏感性分析.
主要成果:
- 干果摄入量显示出与较低的AgeAccelGrim (β=-1.365,P=2.985×10-3) 和AgeAccelPheno (β=-1.933,P=8.371×10-4) 的统计学上显著的关联.
- 多变量MR证实了这些因果作用,对AgeAccelGrim (β=-1.315,P=1.480×10-2) 和AgeAccelPheno (β=-1.595,P=2.483×10-2) 的调整估计.
- 对于其他DNAm标记物没有发现任何显著的关联,敏感性分析表明没有实质性的水平类.
结论:
- 这项MR研究提供了证据表明,增加干果摄入量因果性地降低了GrimAge和PhenoAge的加速.
- 这些发现表明,干果在促进更健康的衰老和可能延长寿命方面可能发挥作用.
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