固体器官移植接受者的严重COVID风险
P Barreiro1, F J Candel, M M Carretero
1Pablo Barreiro MD PhD, Regional Public Health Laboratory. Comunidad de Madrid. Infectious Diseases. Internal Medicine. Hospital General Universitario La Paz. Madrid, Spain. Department of Medical Specialties and Public Health. School of Medicine. Universidad Rey Juan Carlos, 28922 Madrid, Spain. pablo.barreiro@salud.madrid.org.
概括
固体器官移植接受者尽管接种了疫苗,但仍然面临严重COVID-19的高风险. 建议每年接种SARS-CoV-2疫苗,以减少这一脆弱人群的死亡率.
科学领域:
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
- 传染性疾病 传染性疾病
背景情况:
- 固体器官移植 (SOT) 接受者是严重COVID-19的高风险群体,即使使用当前的疫苗接种策略.
- 移植后的免疫抑制和潜在的健康状况增加了对SARS-CoV-2感染和严重结果的易感性.
- 重复的SARS-CoV-2疫苗接种剂量不能完全保护SOT接种者免受感染,疾病或死亡.
研究的目的:
- 突出SOT接收者对COVID-19的持续脆弱性.
- 为了强调当前在这个人群中接种SARS-CoV-2疫苗的局限性.
- 倡导对SOT接种者的持续警和优化疫苗接种方案.
主要方法:
- 对SOT接受者COVID-19结果的当前文献的审查.
- 对免疫抑制群体的疫苗疗效和免疫反应数据的分析.
- 对在SOT患者中导致严重COVID-19的风险因素的评估.
主要成果:
- 与普通人群相比,SOT接收者面临的严重COVID-19的风险更高.
- 疫苗接种虽然减少了死亡率,但并不能消除SOT接种者感染或严重疾病的风险.
- 免疫抑制显著抑制疫苗诱导的幽默和细胞反应.
结论:
- SOT接收者构成了高风险人群,需要特定的COVID-19管理策略.
- 年度SARS-CoV-2疫苗接种对于SOT接种者来说至关重要,以减轻致命的结果.
- 对SOT接种者加强疫苗接种方法的进一步研究是有必要的.
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