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Updated: Jul 10, 2025

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在CART-T后的T细胞感染:病因学,病原和治疗方法

N García-Poutón, O Peyrony, M Chumbita

¹Carolina Garcia-Vidal, Infectious Diseases Department, Hospital Clínic-IDIBAPS, Barcelona, Spain. Carrer de Villarroel 170, 08036, Barcelona, Spain. cgarciav@clinic.cat and carolgv75@hotmail.com.

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

|November 24, 2023

概括

针对B细胞癌的CAR T细胞治疗增加了感染风险. 本综述详细介绍了感染,危险因素和预防策略,如疫苗接种和抗生素,以改善患者的治疗结果.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
传染性疾病传染性疾病

背景情况:

针对CD19的化学抗原受体 (CAR) T细胞疗法是对耐火性B细胞恶性瘤的突破.
这种治疗可以导致显著的免疫损害,增加感染易感性.

研究的目的:

对接受CAR T细胞治疗的人群感染的频谱进行审查.
为了确定感染的关键风险因素.
概述基本的感染预防和管理策略.

主要方法:

关于与CAR T细胞治疗相关的感染的文献综述.
对风险因素的分析,包括皮质类固醇使用,低胺球蛋白血症和细胞因子释放综合征 (CRS).

主要成果:

患者面临细菌,病毒和真菌感染的风险.
严重的CRS,皮质类固醇使用和低免疫球蛋白水平是显著的危险因素.
感染对患者的治疗结果构成重大威胁.

结论:

预防措施,包括疫苗接种和免疫球蛋白替代,至关重要.
建议制定明确的抗生素使用和密切接触者的疫苗接种指南.
优化感染预防对于成功的CAR T细胞治疗结果至关重要.

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