我们在治疗环境中对非黑色素瘤皮肤癌的免疫疗法的立场是什么?
Andrea Alberti1, Cristina Gurizzan1, Alice Baggi1
1Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia at the Azienda Socio Sanitaria Territoriale (ASST)-Spedali Civili, Brescia.
Current opinion in otolaryngology & head and neck surgery
|November 24, 2023
概括
免疫疗法在非黑色素瘤皮肤癌 (NMSC) 中显示出前景. 免疫检查点抑制剂对晚期皮肤状细胞癌 (cSCC) 和默克尔细胞癌 (MCC) 有效,正在进行NMSC新辅助治疗的试验.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 非黑色素瘤皮肤癌 (NMSC) 包括基底细胞癌 (BCC),皮肤状细胞癌 (cSCC) 和默克尔细胞癌 (MCC).
- 高瘤突变负担从紫外线突变发生是NMSCs的一个共同特征.
- 免疫疗法已成为NMSC的有希望的治疗策略.
研究的目的:
- 审查免疫疗法在NMSCs的治疗环境中的应用.
- 突出免疫检查点抑制剂在治疗晚期NMSC中的作用.
- 探索用于NMSCs的新辅助免疫疗法的潜力.
主要方法:
- 对NMSCs免疫疗法的当前文献的综述.
- 对NMSC治疗中免疫检查点抑制剂的临床试验数据的分析.
- 检查转化研究,确定反应的生物标志物.
主要成果:
- 免疫检查点抑制剂是先进的cSCC和MCC的第一线治疗方法,以及BCC的第二线治疗方法.
- 许多临床试验正在调查NMSCs的新辅助免疫检查点阻塞.
- 对cSCC有成熟的临床数据,并且已经确定了有希望的反应生物标志物.
结论:
- 新辅助免疫疗法为NMSC提供了一种有前途的治疗方法,有可能改善患者的生活质量.
- 对NMSC的局部区域治疗可以显著影响功能和化品结果.
- 未来的临床试验结果将对确定新辅助免疫疗法在NMSC管理中的作用至关重要.
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